10 juni 2016 — Effect of potentially modifiable risk factors associated with myocardial Pleiotropic effects of statins: benefit beyond cholesterol reduction?

av AA Pioszak · 2008 · Citerat av 258 — The pleiotropic effects of PTH are mediated primarily through the binding and activation of the PTH receptor (PTH1R), which is highly

Cancer Cell. 2005 Aug;8(2):93-5. Statins and the HMGCoA reductase pathway, beyond cholesterol. Maybe you missed chemistry at high school. Check out the site at www.profmontage.com.au Steroid drugs, such as prednisone and prednisolone, have pleiotropic effects, including systemic ones, for the same reason that endogenous steroid hormones do too: cells throughout the body have receptors that can respond to them, because the endogenous ones are endocrine messengers. 2021-01-28 · Based on numerous studies detailing the beneficial effects of prebiotic GOS, which include modulation of the gut microbiome with specific increases in beneficial bacteria [45, 47], stimulation of tight junctions and enhancement of the intestinal barrier function through modulation of goblet cells , reduction of inflammatory markers release in cell culture models , support of intestinal development and mucosal immune responses , and reduction in adherence of enteropathogenic Se hela listan på ahajournals.org Pleiotropic: Producing or having multiple effects from a single gene.

than pleiotropic effects of statins for endothelial function in patients with dysglycaemia and coronary artery disease. Europ Heart J 2008; 29:1753-1760. 12. av PM NILSSON — Simvastatin versus ezetimibe: pleiotropic and lipid- lowering effects on endothelial function in humans. Circulation. 2005;111(18):2356-63. 16.

Many of these pleiotropic effects are mediated by inhibition of isoprenoids, which serve as lipid attachments for intracellular signaling molecules. In particular, inhibition of small GTP-binding proteins, Rho, Ras, and Rac, whose proper membrane localization and function are dependent on isoprenylation, may play an important role in mediating the pleiotropic effects of statins.

We've been told for years that 1 jan. 2021 — including immunomodulatory activity, protection against respiratory tract infections and pleiotropic effects on the cardiovascular system.

Pleiotropy refers to the phenomenon by which a gene pair at a single locus affects many (more than one) phenotype characteristics. For instance, in albino.

Check out the site at www.profmontage.com.au Steroid drugs, such as prednisone and prednisolone, have pleiotropic effects, including systemic ones, for the same reason that endogenous steroid hormones do too: cells throughout the body have receptors that can respond to them, because the endogenous ones are endocrine messengers. 2021-01-28 · Based on numerous studies detailing the beneficial effects of prebiotic GOS, which include modulation of the gut microbiome with specific increases in beneficial bacteria [45, 47], stimulation of tight junctions and enhancement of the intestinal barrier function through modulation of goblet cells , reduction of inflammatory markers release in cell culture models , support of intestinal development and mucosal immune responses , and reduction in adherence of enteropathogenic Se hela listan på ahajournals.org Pleiotropic: Producing or having multiple effects from a single gene. For example, the Marfan gene is pleiotropic, potentially causing such diverse effects as long fingers and toes (arachnodactyly), dislocation of the lens of the eye, and dissecting aneurysm of the aorta. CONTINUE SCROLLING OR CLICK HERE Indeed, recent studies indicate that some of the cholesterol-independent or “pleiotropic” effects of statins involve improving endothelial function, enhancing the stability of atherosclerotic plaques, decreasing oxidative stress and inflammation, and inhibiting the thrombogenic response. 2015-12-17 · V. PLEIOTROPIC ACTIONS OF VITAMIN D. Over the course of the last decades, it has become increasingly clear that the effects of 1,25(OH) 2 D 3 are not limited to the maintenance of calcium and phosphate homeostasis.

In particular, inhibition of small GTP-binding proteins, Rho, Ras, and Rac, whose proper membrane localization and function are dependent on isoprenylation, may play an important role in mediating the pleiotropic effects of statins. Statins and the HMGCoA reductase pathway, beyond cholesterol.
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A Multicenter, Randomized Double-Blind Study Comparing The Pleiotropic Effects Of Atorvastatin 10 Mg And 80 Mg Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: An expert panel position paper.

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2014-04-08 · 3. Pleiotropic effects of statins. However, the overall clinical benefits observed with statin therapy appear to be greater than what might be expected from changes in lipid profile alone, suggesting that the beneficial effects of statins may extend beyond their effects on serum cholesterol levels.

The term is often used to refer to a single gene defect that is expressed as 2019-09-24 · Although effects are pleiotropic and affect many cell cycle regulators, the main Cyclin-CDK complexes driving progression through G2 phase show differential regulation in CHH cells. Most of the effects of statins can be explained by pleiotropic effects independent of their lowering of serum cholesterol; in some cases, these effects have been shown to be a result of the role lowering effects, to include so-called pleiotropic effects. These cholesterol-independent effects include improving endothelial function, attenuating vascular and myocardial remodeling, inhibiting vascular inflammationand oxida-tion, and stabilizing atherosclerotic plaques.